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FDA has further indicated that the court order continues to permit the agency to determine, at its discretion (i.e., on a case-by-case basis), whether to allow an ENDS product subject to a timely-submitted PMTA to remain on the market after the one-year compliance period ends on September 9, 2021

Additionally 3 authors of the "Guide" admit to having previously accepted money from Pfizer (which sells Champix) or GlaxoSmithKline

And then theres the idea of crossing over into different spaces

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Meanwhile, vaping formaldehyde may deposit cancerous agents into the lungs of e-cigarette users (Jensen et al., 2012)